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Plasma pharmacokinetic parameters of 1 and 2 after a single IV injection
| Parameter | Compound | |
|---|---|---|
| 1 | 2 | |
| I. Non-compartmental analysis | ||
| mg/kg | 7.5 | 5 |
| C max (μg/mL) | 49.4 ± 11.2 | 41.3 ± 5.9 |
| Elimination t 1/2 (hr) | 5.2 | 4.3 |
| MRT (hr) | 3.3 | 4.9 |
| AUC0–t (μg/mL × hr) | 75.8 | 173.5 |
| AUC0–∞ (μg/mL × hr) | 77.4 | 176.5 |
| CL (mL/hr) | 1.8 | 0.6 |
| II. Compartmental analysis | ||
| C max (μg/mL) | 43.6 | 40.2 |
| t 1/2 α (hr) | 0.5 | 0.1 |
| t 1/2 β (hr) | 4.6 | 4.2 |
| V d (mL) | 8.1 | 4 |
| CL (mL/hr) | 2.1 | 0.7 |
| AUC0–∞ (μg/mL × hr) | 67.5 | 144.8 |
