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Tissue pharmacokinetic parameters of 1 and 2 after a single IV injection
| Compound | 1 | 2 | ||
|---|---|---|---|---|
| C max (μg/g) | AUC (μg/g × hr) | C max (μg/g) | AUC (μg/g × hr) | |
| Liver | 11.7 ± 1.3 | 157.7 | 43.8 ± 0.7 | 301.3 |
| Kidney | 27.0 ± 2.9 | 299.2 | 35.1 ± 2.8 | 424.7 |
| Lung | 16.4 ± 1.4 | 130.6 | 256 ± 93.1 | 523.5 |
