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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Mech Ageing Dev. 2012 Aug 19;133(9-10):620–628. doi: 10.1016/j.mad.2012.08.002

Fig. 4. PQ-treatment leads to reduced P/O throughout life.

Fig. 4

(A) In vivo P/O ratio decreases 24 hours after PQ-treatment in young, middle aged, and old mice. Reduced P/O is associated with reduced resting ATPase rate (B) without significant changes in mitochondrial O2 consumption (C) following PQ treatment. The same trend led to a significant decrease in P/O of old relative to young control mice. Data presented as mean ± SEM, n = 4-8, * p< 0.05, **p<0.01 relative to age-matched control, #p<0.05 relative to young control.