Fig. 7. The energetic consequences of ROS-induced uncoupling are amplified by age.
(A) ATPmax was significantly lower in old compared to young controls and PQ treatment led to a significant decline in ATPmax in old mice only. (B) ATP concentration in mixed skeletal muscle decreased significantly in old compared to young controls, and PQ treatment led to significant decreases in ATP in both middle aged and old mice. Data presented as mean ± SEM, n = 4-8, *p<0.05 PQ-treatment vs. age-matched control, ## p<0.01 aged control vs. young control.