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. Author manuscript; available in PMC: 2013 Oct 19.

Published in final edited form as: J Mol Biol. 2012 Jul 9;423(2):143–158. doi: 10.1016/j.jmb.2012.06.042

In this cartoon model of dimerization, Fis1 is depicted as red and gray crescents and the Fis1 arm as a solid, curved line. For dimerization to occur, the interface between the Fis1 arm and concave surface must be disrupted, and the interface between TPR1 and TPR2 must be disrupted. Mutations that disrupt interactions between either the arm and concave surface (ΔN, fis1-3) or TPR1 and TPR2 (L80P, C79S/C87S) allow dimerization of Fis1.

In this cartoon model of dimerization, Fis1 is depicted as red and gray crescents and the Fis1 arm as a solid, curved line. For dimerization to occur, the interface between the Fis1 arm and concave surface must be disrupted, and the interface between TPR1 and TPR2 must be disrupted. Mutations that disrupt interactions between either the arm and concave surface (ΔN, fis1-3) or TPR1 and TPR2 (L80P, C79S/C87S) allow dimerization of Fis1.