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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Bone. 2012 Aug 16;51(5):902–912. doi: 10.1016/j.bone.2012.08.113

Fig. 1. Identification of potential osteoclast regulators by expression profiling.

Fig. 1

(A) Microarray analysis of Nfatc1fl/fl and Nfatc1Δ/Δ OCPs stimulated for 3 d with MCSF and RANKL. Shown is a heat map depicting genes up or down regulated 6-fold. NFATc1-dependent transcripts selected for further study, as well as representative known regulators of osteoclast function are highlighted. (B) Real-time PCR analysis for the expression of the indicated genes in cultures of Nfatc1fl/fl and Nfatc1Δ/Δ OCPs stimulated with MCSF alone or with MCSF and RANKL to stimulate osteoclast differentiation. (*, p<0.05; **, p<0.01; ****, p<0.0001).