Fig 2.

Measurement of IC₅₀ and m using single-round infectivity assay. (A) Log-log dose-response curve for the integrase inhibitor L870812. Each point represents the mean from more than three experiments. The IC₅₀ of L870812 is shown by the arrow. (B) Linearized dose-response curve for L870812 based on median effect model. The IC₅₀ of L870812 is shown by the arrow. (C) Representative flow cytometry plots showing detection of cells that were infected in the absence (left) or presence (right) of 1 μM L870812. (D) Log-log dose-response curve for the protease inhibitor ATV. Each point represents the mean from more than three experiments. The IC₅₀ of ATV is shown by the arrow. (E) Linearized dose-response curve for ATV based on median effect model. The IC₅₀ of ATV is shown by the arrow. (F) Representative flow cytometry plots showing detection of cells that were infected with virions generated in the absence (left) or presence (right) of 1 μM ATV.