Fig 3.

CTL targeting of epitopes from structural proteins early in infection correlates with better long-term outcomes. (a) Column height indicates the number of unique epitopes targeted within each individual. White, gray, and black shading, portion of the response that is specific for epitopes of structural, regulatory, and accessory protein origin, respectively. The greater breadth of the CTL response to both total structural epitopes (b) and B57-restricted structural epitopes (c) correlates similarly with slower progression to disease. The strength and statistical significance of the associations shown in panels b and c were similar when the analysis was adjusted for the effect of the time of sampling on the breadth of targeting and when data for participant N were excluded. Data for all participants are represented in the graphs. Correlations and P values shown are calculated on the basis of Spearman's rank correlation.