Table 1.
Participant | HLA genotype | Characteristics at time of sampling |
Long-term outcome |
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---|---|---|---|---|---|---|---|---|---|---|---|
Time (mo) since infectiona | CD4b | VLc | Event | Time (yr) to eventd | |||||||
A | A0100 | A3000 | B1801 | B5701 | C0501 | C0602 | 0–12 | 833 | 20,501 | Death | 3.5 |
B | A0201 | A3301 | B3501 | B5701 | C0401 | C0602 | 5–6 | 789 | 14,811 | Death | 5.5 |
C | A0101 | A0201 | B4402 | B5701 | C0501 | C0602 | 0–24 | 317 | 30,468 | CD4 < 200 | 6 |
D | A0101 | A2402 | B4401 | B5701 | C0304 | C0602 | 0–6 | 1098 | 8,868 | CD4 < 200 | 6 |
E | A0201 | A0201 | B5001 | B5701 | C0602 | C0602 | 10–15 | 800 | 2,927 | CD4 < 200 | 6.25 |
F | A0101 | A0201 | B0702 | B5701 | C0602 | C0702 | 0–6 | 744 | 11,955 | CD4 < 200 | 9 |
G | A0101 | A0201 | B5701 | B5701 | C0602 | C0702 | 0–7 | 665 | 4,414 | CD4 < 200 | 11 |
H | A0101 | A2501 | B1801 | B5701 | C0602 | C1203 | 0–6 | 1637 | 3,151 | CD4 < 200 | 12 |
I | A0201 | A0201 | B1501 | B5701 | C0304 | C0602 | 3–8 | 958 | 4,989 | cART | 13 |
J | A0100 | A2400 | B4403 | B5701 | C0303 | C0602 | 4–6 | 801 | 43,400 | Nonee | 13 |
K | A0101 | A0201 | B5101 | B5701 | C0602 | C0702 | 0–6 | 757 | 109,373 | CD4 < 200 | 13.5 |
L | A0200 | A3201 | B0702 | B5701 | C0602 | C0700 | 9–15 | 853 | 82,009 | CD4 < 200 | 15 |
M | A0201 | A6801 | B5703 | B5802 | C0602 | C1801 | 6–12 | 642 | 5,538 | cART | 17 |
N | A0101 | A0301 | B1518 | B5701 | C0602 | C0704 | 0–9 | 1200 | < 400 | Nonee | 25 |
Number of months that elapsed between seroconversion and donation of the samples used in this study.
Number of CD4+ T lymphocytes/mm3 of blood at the time of sampling.
Number of HIV-1 RNA copies/ml of plasma at the time of sampling.
Number of years elapsed between date of infection and the earliest of the following events: decline of CD4+ T cell counts below 200/mm3, initiation of combination antiretroviral therapy (cART), or death.
Participants J and N still had CD4 counts above 200, as of 2011.