Table 2.
Best-fit viral kinetic parameters for WT and MUT A/Brisbane/59/2007a
| Parameter | Value (95% CI) |
P valueb | |
|---|---|---|---|
| WT | MUT | ||
| Mean eclipse period, τE (h) | 6.1 (6.0–6.7) | 8.0 (7.4–9.1) | <0.001 |
| Eclipse period SD, σE (h) | 0.47 (0.46–0.92) | 1.2 (0.83–1.9) | 0.014 |
| Infecting time, tinfect (min) | 18 (13–21) | 3.4 (2.0–5.1) | <0.001 |
| MDCKα2,6 infectious life span, τI (h) | 14 (11–18) | 16 (10–23) | 0.57 |
| Virion infectious half-life, ln2/c (h) | 3.7 (3.4–4.0) | 3.5 (3.1–3.9) | 0.43 |
| Basic reproductive no., R0 | 1.7 (1.1–3.3) × 103 | 48 (17–158) × 103 | <0.001 |
a
Fitted parameter values for WT and MUT A/Brisbane/59/2007 with 95% CIs from bootstrap replicates of SC and MC viral yield experiments. For the data and fitted model curves, see the supplemental material.
b
WT versus MUT.