Table 1.
Antibiotic susceptibilities in clinical isolates from the study case
| Isolate | Description | Day of DAP CPT combination therapy | MIC (μg/ml)a |
||||||
|---|---|---|---|---|---|---|---|---|---|
| DAPb | VANb | CPTc | DAP/VAN with CPT 0.5 μg/mlb | OXAc | DAP/VAN with OXA 128 μg/mld | DAP/VAN with OXA 0.5 μg/mld | |||
| W3148 | Initial blood culture | −6 | 0.75–1.0 | 2.0 | 1.0 | 0.06/0.5 | 256 | 0.25/0.75 | 0.38/1.5 |
| W3248 | Final blood culture | 4 | 2.0 | 3.0 | 1.0 | 0.06/0.5 | 256 | 0.06/1.0 | 0.25/1.5 |
| W3278 | Initial seeded wrist culture | 7 | 0.13 | 1.5 | 1.0 | 0.06/0.5 | 256 | 0.06/1.5 | 0.13/1.5 |
| W3348 | Final seeded wrist culture | 14 | 0.19 | 1.5 | 1.0 | 0.06/0.5 | 256 | 0.13/0.75 | 0.13/1 |
a
Abbreviations: DAP, daptomycin; VAN, vancomycin; CPT, ceftaroline; OXA, oxacillin.
b
Determined by Etest.
c
Determined by broth microdilution.
d
Values represent DAP and VAN Etest results after incorporation of CPT or OXA into the MHA medium.