Table 2.
Daptomycin cell membrane effects in isolates from the patient
| Isolate | % of intact cell membranes after daptomycin exposure ata: |
Membrane fluidity (pI)b | |||
|---|---|---|---|---|---|
| 6 mg/kg | 8 mg/kg | 10 mg/kg | 12 mg/kg | ||
| W3148 | 22.4 ± 4.2 | 25.7 ± 1.4 | 17.9 ± 1.7 | 18.3 ± 3.2 | 0.294 ± 0.018 |
| W3248 | 43.0 ± 10.0 | 29.7 ± 1.4 | 16.9 ± 1.9 | 17.1 ± 3.1 | 0.288 ± 0.016 |
| W3278 | 22.1 ± 4.2 | 20.6 ± 0.5 | 20.2 ± 1.3 | 18.5 ± 0.7 | 0.284 ± 0.020 |
| W3348 | 32.7 ± 5.7 | 20.5 ± 1.4 | 19.5 ± 1.0 | 18.3 ± 0.5 | 0.287 ± 0.020 |
a
Values are means ± standard deviations. A lower percentage of intact cell membranes indicates greater daptomycin activity.
b
A lower pI value indicates a greater degree of membrane fluidity.