Table 7.

Summary of predominant resistance substitutions selected during inhibitor treatment

Target(s) of inhibitors used for selection	Resistance substitution(s)
	Genotype 1b			Genotype 1a
	NS3	NS5A	NS5B	NS3	NS5A	NS5B
NS3	D168V			R155K
NS5A		L31M, Y93H			Q30H
NS5B			P495A/S/L			P495L
NS3, NS5A	N77S, R155Q	R30Q/H, L31M, Y93H		R155K, D168N/G	Q30H, M28T
NS5A, NS5B		R30Q/H, L31M/F, Y93H	P495A/S/L		Q30H	L392I, P495S/L
NS3, NS5A, NS5B	Q41R, Q80R, R155Q	R30Q/H, L31M, Y93H	P495A	Q80R, R155K, D168E	Q30H	P495L, T389I-A421V