Table 2.
MICs of 13 isolates possessing genes encoding IMP-8 to 12 antimicrobial agentsa and their pulsotypes
| Isolate no. (hospital) | Bacterium (designation) | ESBL production/MHT result | MIC (μg/ml) |
Pulsotype | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FEP | ATM | ERT | DOR | IMI | MEM | GM | AN | FOS | SXT | CL | TGC | ||||
| 1 (A) | K. pneumoniae (I) | +/+ | 32 | 0.5 | 8 | 2 | 2 | 1 | 1 | 2 | 256 | >32 | 0.5 | 4 | PT-3 |
| 2 (A) | K. pneumoniae (II) | +/+ | 16 | 0.25 | 4 | 1 | 1 | 0.5 | 1 | 2 | 256 | >32 | 0.5 | 4 | PT-3 |
| 3 (A) | K. pneumoniae (III) | +/+ | 16 | 0.25 | 4 | 1 | 0.5 | 0.5 | 1 | 2 | >256 | >32 | 0.5 | 1 | PT-4 |
| 4 (H) | K. pneumoniae (IV) | +/+ | 32 | 16 | 4 | 0.5 | 0.5 | 0.5 | 32 | 1 | 32 | >32 | 0.5 | 2 | PT-2 |
| 5 (H) | K. pneumoniae (V) | +/+ | 32 | 16 | 2 | 0.5 | 0.5 | 0.5 | 32 | 1 | 64 | >32 | 0.5 | 2 | PT-2 |
| 6 (A) | E. coli | +/+ | 32 | 64 | 1 | 0.12 | 0.5 | 0.12 | 128 | 2 | 1 | >32 | 0.5 | 0.5 | NP |
| 7 (K) | E. cloacae | NA/+ | 8 | 128 | 1 | 0.25 | 0.5 | 0.25 | 128 | 8 | 8 | >32 | 0.5 | 1 | PT-5 |
| 8 (K) | E. cloacae | NA/+ | 8 | 128 | 1 | 0.06 | 0.25 | 0.12 | 128 | 8 | 16 | >32 | 0.25 | 4 | PT-6 |
| 9 (K) | E. cloacae | NA/+ | 16 | >128 | 4 | 0.25 | 0.5 | 0.25 | 1 | 1 | 32 | >32 | 0.5 | 4 | PT-7 |
| 10 (K) | E. cloacae | NA/+ | 2 | 128 | 2 | 0.12 | 0.25 | 0.25 | 1 | 1 | 32 | >32 | 0.5 | 4 | PT-7 |
| 11 (E) | E. cloacae | NA/− | 2 | 128 | 1 | 0.06 | 0.12 | 0.06 | 128 | 8 | 32 | >32 | 0.25 | 2 | PT-8 |
| 12 (A) | K. oxytoca | +/− | 16 | 0.25 | 2 | 0.5 | 1 | 0.5 | 1 | 1 | 16 | 0.25 | 0.5 | 1 | NP |
| 13 (E) | C. freundii | NA/+ | 64 | 128 | 4 | 1 | 2 | 0.5 | 128 | 2 | 0.5 | 0.12 | 0.5 | 0.5 | NP |
a
AN, amikacin; ATM, aztreonam; CL, colistin; DOR, doripenem; ERT, ertapenem; ESBL, extended-spectrum β-lactamase production detected by the disk diffusion method (10); FEP, cefepime; FOS, fosfomycin; GM, gentamicin; IMI, imipenem; MEM, meropenem; MHT, modified Hodge test (11); NA, not available; NP, not performed; SXT, trimethoprim-sulfamethoxazole; TGC, tigecycline.