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Selectivity of ASVa
| Virus | Cell type | EC50 (μM) | CC50 (μM)a |
|---|---|---|---|
| HCV-1ab | HuH-7 | 0.004 ± 0.0003 | 25 ± 5 |
| BVDVc | HuH-7 | 12 ± 2 | 32 ± 4 |
| HCoVOC43 | MRC5 | >32 | 32 ± 5 |
| HRV2 | MRC5 | >32 | 32 ± 5 |
| HIV | MT-2 | 13 ± 2 | 34 ± 3 |
| NA | HepG2 | NA | 38 ± 5 |
| NA | HeLa | NA | 19 ± 1 |
| NA | HEK293 | NA | 11 ± 2 |
Data are means ± standard deviations from at least three independent experiments. NA, not applicable.
Subgenomic replicon.
Full-length replicon.
