Table 1.
MICs of TMP and SMX against drug-susceptible and drug-resistant M. tuberculosis strains
| Strain | Drug resistance(s)a | Genotypeb | MIC (μg/ml) |
Source and/or reference | |
|---|---|---|---|---|---|
| TMP | SMX | ||||
| H37Rv | 512 | 8.5 | Trudeau Institute | ||
| CDC1551 | 512 | 2.1 | CSU | ||
| Beijing | 512 | 34 | Laboratory stock | ||
| Erdman | 1,024 | 8.5 | Trudeau Institute | ||
| V4207 | 256 | ≤2.1 | 8; clinical isolate from KwaZulu-Natal, South Africa | ||
| V9124 | 512 | 8.5–17 | 8; clinical isolate from KwaZulu-Natal, South Africa | ||
| H37Rv/pMV261::dhfr | 1,024 | 17 | 22 | ||
| mc24977 | INH | katG del371g | 128 | 8.5 | Laboratory strain (H37Rv background) |
| CI5447 | INH | ND | 512 | 17 | Clinical isolate from Mexico |
| CI5297 | INH | ND | 256 | ≤2.1 | 20; clinical isolate from Mexico |
| mc24986 | RIF | rpoB H445R | 512 | 4.25 | Laboratory strain (H37Rv background) |
| CVOF1 | OF | ND | 1,024 | 8.5 | Laboratory strain (H37Rv background) |
| mc24914 | INH, ETH | PmabAinhA(c-15t) | 512 | 8.5 | 21; laboratory strain (H37Rv background) |
| mc24997 | INH, RIF | katG del, rpoB H451W | 512 | 8.5 | Laboratory strain (H37Rv background) |
| mc25854 | INH, RIF | katG L546P, rpoB S450L | 512 | 8.5 | Laboratory strain (H37Rv background) |
| mc25857 | INH, RIF | katG S315I, rpoB S450L | 512 | 8.5 | Laboratory strain (H37Rv background) |
| mc25858 | INH, RIF | katG insg317, rpoB H445D | 512 | 8.5 | Laboratory strain (H37Rv background) |
| CI5058 | INH, RIF | ND | 512 | 8.5 | Clinical isolate from Mexico |
| CI5324 | INH, RIF | 512 | 8.5 | 20; clinical isolate from Mexico | |
| CI5400 | INH, RIF | 512 | 8.5 | 20; clinical isolate from Mexico | |
| V2475 | INH, RIF | 512–1,024 | 17 | 8; clinical isolate from KwaZulu-Natal, South Africa | |
| mc25855 | INH, RIF, OF | katG del, rpoB H451W, gyrA A90V | 512 | 4.25 | Laboratory strain (H37Rv background) |
| mc25856 | INH, RIF, SM | katG del, rpoB H451W, rrs c516t | 512 | 4.25 | Laboratory strain (H37Rv background) |
| CI5072 | INH, RIF, SM | ND | 1,024 | 8.5 | 20; clinical isolate from Mexico |
| CI5071 | INH, SM | ND | 512 | 4.25 | 20; clinical isolate from Mexico |
| CI5358 | INH, EMB, ETH | ND | 512 | 8.5 | 20; clinical isolate from Mexico |
| CI5459 | INH, EMB, ETH | ND | 256 | 8.5 | Clinical isolate from Mexico |
| CI5483 | EMB, SM | ND | 512 | 8.5 | Clinical isolate from Mexico |
| CI12081 | INH, RIF, SM, EMB, ETH | ND | 128 | 2.1 | Clinical isolate from Mexico |
| TF275 | INH, RIF, SM, EMB, OF, KM | 640 | 8.5 | 8; clinical isolate from KwaZulu-Natal, South Africa | |
a
OF, ofloxacin; ETH, ethionamide; SM, streptomycin; EMB, ethambutol; KM, kanamycin.
b
ND, not determined.