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Effect of DTT and ascorbic acid on the anti-T. cruzi activity of vitamin B12a
| Antioxidant concn (μM) | Vitamin B12 activity (μM) | Inhibition (%) |
|---|---|---|
| None | 0.25 | 5.4 ± 1.5 |
| DTT | ||
| 0.5 | 0 | 5.9 ± 1.9 |
| 1.0 | 0 | 21.3 ± 2.4 |
| 0.5 | 0.25 | 23.9 ± 1.8 |
| 1.0 | 0.25 | 41.4 ± 2.2 |
| Vitamin C | ||
| 0.5 | 0 | 3.7 ± 1.7 |
| 1.0 | 0 | 2.4 ± 1.2 |
| 1.5 | 0 | 10.3 ± 1.4 |
| 0.5 | 0.25 | 18.4 ± 1.2 |
| 1.0 | 0.25 | 22.9 ± 1.6 |
| 1.5 | 0.25 | 47.7 ± 1.9 |
Zero percent inhibition corresponds to parasites cultured in the absence of either B12 or antioxidant compound.
