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Time-kill studies of CB-183,315 at 16× the MIC against three strains of C. difficile, including RMA 19139, a NAP1 strain from RM Alden Laboratory, ATCC 43596, a toxigenic clinical isolate, and ATCC 700057, a nontoxigenic strain used for susceptibility testing. MICs against CB-183,315 for these strains were 0.06 μg/ml for the NAP1 strain, 0.06 μg/ml for the toxigenic strain, and 0.25 μg/ml for the nontoxigenic strain. CB-183,315 was bactericidal against all three strains of C. difficile.
