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. 2012 Oct;56(10):5023–5030. doi: 10.1128/AAC.00057-12

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Copyright © 2012, American Society for Microbiology. All Rights Reserved.

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Fig 8 — Dose- and time-dependent efficacy of CB-183,315 (A) and vancomycin (B) against C. difficile ATCC 43596 in the hamster model of C. difficile-associated diarrhea (CDAD). Note that this animal model of CDAD is rapidly lethal for 100% of control hamsters dosed with deionized water; all five hamsters dosed with this vehicle were found dead on day 2. CB-183,315 and vancomycin produced similar patterns of dose- and time-dependent survival in this model. These data are from one of three studies comparing doses of CB-183,315 and vancomycin in this hamster model. Data from all three hamster studies are compared and compiled in Tables 2 and 3.