Table 2.

Therapeutic efficacy of CB-183,315 and vancomycin against initial hamster CDAD evaluated on day 6 (1 day after the last dose)^a

Study	% (no.) of hamsters surviving initial CDAD after receiving:
	Sterile water (0.5 ml)	CB-183,315			Vancomycin
		2 mg/kg	10 mg/kg	25 mg/kg	2 mg/kg	10 mg/kg	25 mg/kg
1	0	100	100	100	100	100	100
2	0	100	87.5	100	100	100	100
3b	0	100	100	Not done	100	100	Not done
Overall	0 (15)	100 (32)	97 (32)	100 (16)	100 (24)	100 (24)	100 (16)

^aAll hamsters were dosed twice daily by oral gavage for 5 days, starting 12 h after inoculation with C. difficile. Sentinel hamsters (n = 17) were not inoculated with C. difficile spores and received sham dosing with empty needles and syringes; survival of sentinels was 100% in all studies.

^bIn study 3, the initial number was 16 each for the 2-mg/kg and 10-mg/kg CB-183,315 treatment groups.