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(A) Fit of the three-compartment pharmacokinetic model to the serum data from the population. Predicted concentration = 0.59 + (0.99 × observed concentration); r2 = 0.35. (B) Observed-predicted values for fit of Bayesian estimates to the data from each individual patient. Predicted concentration = 0.77 + (1.16 × observed concentration); r2 = 0.56.
