Fig 3.

Pharmacokinetics of liposomal amphotericin B administered at different doses. Liposomal amphotericin B was given at a dose of 3 mg/kg/day (A) and in doses of 10 mg/kg, 5 mg/kg, and 5 mg/kg at 0, 48, and 120 h, respectively (B). The open circles are the raw data points from patients (n = 14 in each group; 28 patients total). The solid black line is the mean concentration-time profile of liposomal amphotericin B for a patient weighing 68 kg. The broken lines in both panels represents the 5th and 95th percentile for the simulated population.