Fig 3.

Viability of stationary-phase cultures of arylomycin-susceptible E. coli and S. aureus strains. Stationary-phase cultures of E. coli (A) and S. aureus (B) were washed and diluted into PBS and treated with vehicle controls (open diamonds) or with arylomycin A-C₁₆ at concentrations 2-fold (open squares) or 8-fold (open triangles) above the respective MICs. Cultures of S. aureus whose growth had been arrested by the addition of tetracycline were treated with vehicle controls (open diamonds) or with arylomycin A-C₁₆ at 8 times the MIC (open triangles) (C). A 3-log kill is used as the definition of bactericidal activity and is represented by dashed lines.