Table 3.
MICs of antibiotics alone and FIC indexesa of antibiotics in combination with arylomycin A-C16
| Antibiotic |
E. coli PAS0260 |
S. aureus PAS8001 |
||||
|---|---|---|---|---|---|---|
| MIC (μg/ml) | FICmin | FICmax | MIC (μg/ml) | FICmin | FICmax | |
| Cephalexin | 12 | 0.70 ± 0.19 | 1.14 ± 0.07 | 4 | 0.65 ± 0.06 | 1.38 ± 0.42 |
| Gentamicin | 1 | 0.55 ± 0.11 | 0.91 ± 0.25 | 0.5 | 0.46 ± 0.12 | 0.83 ± 0.22 |
| Tetracycline | 1.5 | 1.10 ± 0.06 | 2.68 ± 0.89 | 0.25 | 0.73 ± 0.06 | 1.36 ± 0.40 |
| Erythromycin | 128 | 0.90 ± 0.21 | 1.28 ± 0.14 | 1 | 0.79 ± 0.26 | 1.15 ± 0.06 |
| Trimethoprim | 0.25 | 0.90 ± 0.21 | 1.58 ± 0.50 | 2 | 1.05 ± 0.03 | 2.55 ± 1.02 |
| Ciprofloxacin | 0.023 | 0.80 ± 0.11 | 1.23 ± 0.06 | 0.25 | 0.63 ± 0.08 | 1.39 ± 0.38 |
| Rifampin | 24 | 0.50 ± 0.00 | 1.03 ± 0.22 | 0.008 | 1.06 ± 0.00 | 2.85 ± 1.25 |
| Polymyxin B | 1 | 0.78 ± 0.30 | 1.15 ± 0.32 | — | — | — |
| Vancomycin | —b | — | — | 2 | 0.80 ± 0.11 | 1.23 ± 0.06 |
| Arylomycin A-C16 | 1 | — | — | 4 | — | — |
a
FICmin and FICmax, minimum and maximum FIC indexes observed, respectively. Values are averages ± standard deviations.
b
—, not determined.