Table 1.
Characteristics of study subjects receiving oral solithromycin at 400 mg once daily for 5 daysa
| Sampling time (h)b | Sexc (n) | Age (yr) | Height (cm) | Wt (kg) | Body mass index (kg/m2) | Total cell count in BAL fluid (cells/mm3) | Macrophages (%) |
|---|---|---|---|---|---|---|---|
| 3 | M (6) | 36 ± 10 | 177 ± 7 | 83.7 ± 10.5 | 26.9 ± 3.0 | 182 ± 106 | 85 ± 9 |
| 6 | M (6) | 38 ± 6 | 175 ± 8 | 83.8 ± 7.3 | 27.3 ± 4.1 | 215 ± 76 | 83 ± 3 |
| 9 | M (6) | 32 ± 4 | 178 ± 8 | 87.6 ± 7.2 | 27.4 ± 2.1 | 163 ± 58 | 82 ± 6 |
| 12 | M (3), F (3) | 32 ± 11 | 165 ± 8 | 81.5 ± 15.5 | 26.2 ± 4.6 | 218 ± 276 | 61 ± 22d |
| 24 | M (3), F (3) | 30 ± 11 | 169 ± 10 | 74.4 ± 16.3 | 25.7 ± 3.0 | 332 ± 514 | 74 ± 15 |
a
Data are expressed as mean ± SD except for sex.
b
Six subjects per sampling time.
c
M, males; F, females.
d
The percentage of macrophages in BAL fluid at the 12-h sampling time was statistically significantly (P < 0.05) lower than those at the 3-h and 6-h sampling times.