Table 3.
Relationship between TMIC and log change in viable count of Acinetobacter baumannii after 24 and 48 h of exposure to doripenem
| Effect | % TMIC for the indicated strains at the following times: |
|||||||
|---|---|---|---|---|---|---|---|---|
| 24 h |
48 h |
|||||||
| 33980 (0.45)a | 28893 (0.75) | 7186 (3.0) | Mean ± SD | 33980 (0.45) | 28893 (0.75) | 7186 (3.0) | Mean ± SD | |
| Static | 30 | 21 | 9 | 20 ± 11 | 30 | 22 | 14 | 22 ± 8 |
| −1 log drop | 32 | 30 | 14 | 25 ± 10 | 32 | 36 | 21 | 30 ± 7 |
| −2 log drop | 37 | 43 | 20 | 33 ± 12 | 36 | 56 | 29 | 40 ± 14 |
| −3 log drop | —b | 77 | 27 | — | — | — | 39 | |
| R2 for model | 0.95 | 0.95 | 0.96 | 0.99 | 0.98 | 0.97 | ||
a
Data in parentheses are MICs (in mg/liter).
b
—, endpoint not achieved.