Table 4.

Risk of emergence of resistance in P. aeruginosa and A. baumannii after exposure to doripenem over 48 h

Organism-exposure and % TMIC	No. of experiments	Growth on 4× MIC plates		Growth on 8× MIC plates		Growth on 16× MIC plates
		No. of occasions	Count (log CFU/ml)	No. of occasions	Count (log CFU/ml)	No. of occasions	Count (log CFU/ml)
P. aeruginosa at 24 h of exposure
12.5	4	2	6.0	0	<2	0	<2
25–37.5	6	1	6.7	0	<2	0	<2
50–75	6	0	<2	0	<2	0	<2
≥85	5	0	<2	0	<2	0	<2
P. aeruginosa at 48 h of exposure
12.5	4	4	6.4 ± 1.0	2	8.0	0	<2
25–37.5	6	2	7.6	2	6.5	0	<2
50–75	6	3	5.6 ± 0.8	3	4.7 ± 1.6	0	<2
≥85	5	2	5.4	1	5.0	0	<2
A. baumannii at 24 h of exposure
12.5	1	1	5.7	1	5.7	0	<2
25–49	6	0	<2	0	<2	0	<2
50–80	5	0	<2	0	<2	0	<2
≥85	3	0	<2	0	<2	0	<2
A. baumannii at 48 h of exposure
12.5	1	1	5.7	1	5.7	1	3.9
25–49	6	2	4.6	2	4.2	7	4.8
50–80	5	1	5.0	1	4.6	0	<2
≥85	3	1	3.9	1	3.5	0	<2