Table 5.

Population profiles of P. aeruginosa strain 38475 and A. baumannii strain 33980 before and after exposure to doripenem^a

Time (h)	Dose regimen (mg)	Viable count on recovery medium with indicated multiple of doripenem MIC
		P. aeruginosa			A. baumannii
		0×	4×	8×	0×	4×	8×
0	500	6.2 ± 0.1	<2	<2	6.1 ± 0.1	<2	<2
	1,000	6.2 ± 0.2	<2	<2	6.5 ± 0.1	<2	<2
	2,000	6.3 ± 0.1	<2	<2	6.1 ± 0.1	<2	<2
	3,000				6.1 ± 0.1	<2	<2
48	500	4.6 ± 1.7	<2	<2	4.7 ± 0.3	4.7 ± 0.4	<2
	1,000	3.6 ± 0.5	<2	<2	4.9 ± 0.4	4.6 ± 0.3	<2
	2,000	4.4 ± 1.4	<2	<2	2.9 ± 1.0	2.7 ± 0.7	<2
	3,000				4.0 ± 0.3	3.7 ± 0.2	<2
96	500	6.6 ± 1.4	2.9 ± 1.0	<2	3.9 ± 0.8	3.8 ± 0.8	<2
	1,000	5.3 ± 0.3	<2	<2	5.0 ± 0.9	4.7 ± 0.6	<2
	2,000	4.4 ± 1.6	<2	<2	3.5 ± 1.5	3.5 ± 1.5	<2
	3,000				4.2 ± 0.2	3.9 ± 0.2	<2

^aDose simulations of 500 mg, 1,000 mg, 2,000 mg, or 3,000 mg every 8 h over 96 h were used.