Table 1.
Pathways represented by genes that are differentially regulated during proliferation arrest in monolayer cultures
| Pathway | No. of proteins |
P value | FDR | Gene IDs | |
|---|---|---|---|---|---|
| In pathway | From study | ||||
| p53 signaling pathway | 12 | 4 | 2.062e−04 | 5.900e−02 | CCND1, CCNE1, CDKN1A, GADD45A |
| FOXM1 transcription factor network | 38 | 6 | 3.115e−04 | 4.200e−02 | AURKB, CCND1, CCNE1, CENPA, ETV5, FOXM1 |
| p53 signaling pathway | 54 | 7 | 3.236e−04 | 2.867e−02 | CCNG2, DDB2, GADD45A, GTSE1, PERP, SERPINE1, THBS1 |
| Cell cycle | 112 | 10 | 3.543e−04 | 2.300e−02 | BUB1B, CCNA1, CCND1, CCNE1, CDC25A, CDC6, CDKN1A, CDKN1C, DBF4, GADD45A |
| G1/S transition | 98 | 9 | 5.743e−04 | 3.160e−02 | CCNA1, CCNE1, CDC25A, CDC6, CDKN1A, DBF4, FBXO5, MCM10, PRIM1 |
| Aurora A signaling | 62 | 7 | 7.291e−04 | 3.350e−02 | AURKA, AURKB, CENPA, GADD45A, MALT1, NFKBIA, TNFAIP3 |
| Telomere maintenance | 30 | 5 | 7.836e−04 | 3.114e−02 | FEN1, POLD4, PRIM1, RFC3, TINF2 |
| Cyclins and cell cycle regulation | 19 | 4 | 1.142e−03 | 4.138e−02 | CCNA1, CCND1, CCNE1, CDKN1A |
| Cell cycle: G1/S checkpoint | 22 | 4 | 1.944e−03 | 6.022e−02 | CCNA1, CCND1, CCNE1, CDKN1A |
| DNA replication | 95 | 8 | 1.992e−03 | 5.560e−02 | CDC6, CDKN1A, DBF4, FEN1, MCM10, POLD4, PRIM1, RFC3 |
| S phase | 97 | 8 | 2.263e−03 | 5.645e−02 | CCND1, CDC25A, CDC6, CDKN1A, FEN1, POLD4, PRIM1, RFC3 |
| Integrin signaling | 39 | 5 | 2.460e−03 | 5.575e−02 | CTGF, CYR61, FN1, PLAU, PLAUR |
| p53 pathway | 58 | 6 | 2.690e−03 | 5.746e−02 | CCNE1, DDB2, GADD45A, GTSE1, PERP, THBS1 |