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Schematic cartoon of the signaling pathways hypothetically induced by N. lactamica PorB and wtPorB following differential TLR2 interaction. While both wtPorB and N. lactamica PorB induce NF-κB-dependent IL-8 and RANTES production downstream of TLR2 activation, only wtPorB also induces IL-8 production via activation of MAP kinases, resulting in enhanced IL-8 levels.
