Fig 4.

Production of TGF-β at different time points by bone marrow-derived macrophages (BMDM) in response to wild-type and Tx5 N. brasiliensis (A) or to increasing concentrations of isolated wall-associated lipids from N. brasiliensis (B). Production of TGF-β at different time points by dendritic cells in response to wild-type and Tx5 N. brasiliensis (C) or to increasing concentrations of isolated wall-associated lipids from N. brasiliensis (D). As controls, cells were uninfected or unstimulated with lipids (0 μg in panels B and D). Data expressed as means ± standard deviations. *, P < 0.05; **, P < 0.001; ***, P < 0.0001 as assessed using a Bonferroni posttest.