TABLE 2.
Epo Pharmacokinetics According to Dosage (Mean ± SD)
| Parameter | 250 U/kg | 500 U/kg | 1000 U/kg | 2500 U/kg |
|---|---|---|---|---|
| AUC ([U*h]/L)a | 18 426 ± 8976 | 50 306 ± 7426b | 131 054 ± 17 083b | 328 002 ± 61 945b |
| Cmax (U/L)a | 3156 ± 1615 | 7046 ± 814b | 13 780 ± 2674b | 33 316 ± 7377b |
| Cl (mL/h per kg)c | 15.6 ± 6.3 | 10.1 ± 1.5d | 7.7 ± 0.9e | 7.9 ± 1.5e |
| t1/2 (h)c | 7.6 ± 6.9 | 7.2 ± 1.9 | 15.0 ± 4.5d | 18.7 ± 4.7e |
| MRT (h)a | 8.7 ± 6.6 | 9.6 ± 1.7 | 19.1 ± 5.2d | 23.0 ± 5.4e |
| Vss (mL/kg) | 133 ± 119 | 95 ± 18 | 146 ± 38 | 178 ± 48 |
| Varea (mL/kg) | 170 ± 178 | 104 ± 25 | 166 ± 48 | 209 ± 60 |
Cl, clearance; t1/2, terminal half-life; Vss, steady-state volume of distribution; Varea, volume of distribution using the area method.
a
P < .0001 (ANOVA).
b
P < .001 (Tukey HSD, compared with 250 U/kg).
c
P < .001 (ANOVA).
d
P < .05 (Tukey HSD, compared with 250 U/kg).
e
P < .01 (Tukey HSD, compared with 250 U/kg).