Figure 3.

CRP expression in the transitional area and minute CRP-positive foci in a distant sample. (a) The transitional zone of an adenoma without steatosis (T) and steatotic adjacent liver (AL) in hematoxylin-eosin (HE) staining. (b) The same area as (a) in CRP immunostaining showing diffuse increase of CRP in the tumor part. (c) CRP immunostaining of a nontumorous liver sample distant from the tumor showing 3-minute CRP foci (arrows). The preserved architecture of the hexagonal liver lobules is highlighted by the vague expression of CRP which outlines the peripheral boundaries of the lobules. (d) Detail of a minute CRP-positive focus in HE showing an area in the lobule with slightly dilated sinusoids, more eosinophilic hepatocytes, and absence of steatosis which is present outside the contours of this focus (arrowheads). (e) The CRP expression of the focus described in (d).