Figure 1.

(A and B) Transmission electron microscopy images of 3-Chloro-4-[(4- methoxyphenyl)amino]furo[2,3-b]quinoline (PK-L4)-loaded solid lipid nanoparticles (SLNs) with polyethylene glycol (PEG)-monostearate: (A) macro view, original magnification (50,000×); (B) microscopic view (70,000×). (C) Schematic depiction of a PK-L4-loaded SLN system.

Notes: The PK-L4 (yellow particle) entrapped in the inner cores of the SLNs (light blue) with Gelucire^® 53/10 (black), hydrogenated soybean phosphatidylcholine (HSPC) (purple), and the positive charge of stearylamine chelated in the core-shell, Pluronic^® F 68 (F-68) (pink), connected to those of the surfactant, and functionalized with PEG (blue) (left), followed by the assembly of those of the surfactant on the core shells of the SLNs (right). The fully assembled PK-L4-loaded SLN system is shown on the right.