Figure 1.

(A–E) Design of the size-based filter microchip. (A) Assembly of a size-based filter microchip; (B) functionality of the size-exclusion-based filter microchip (i) cross-section of the assembled device, (ii) injection of blood into the inlet through a pipette, (iii) injection of PBS into the inlet chamber to wash platelets and plasma through the microchannel and into the output channel, (iv) collection of plasma from the outlet; (C) the experimental chart for validation of virus recovery using filter microchips; (D)

the device during filtration; (E) close-up of the plasma separated by the filter membrane.

Abbreviations: PBS, phosphate-buffered saline; RT-PCR, reverse transcriptase–polymerase chain reaction.