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. 2012 Oct;140(4):391–402. doi: 10.1085/jgp.201210798

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© 2012 Dürrnagel et al.

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Figure 6. — Permeability ratio P_Ca/P_Na of HyNaC is comparable to P2X4. (A) I/V relations of HyNaC2/3/5 in solutions containing 1 or 10 mM CaCl₂ and no NaCl (which had been replaced by 140 or 126.5 mM NMDG-Cl, respectively) and in a solution containing 140 mM NaCl and 1 mM CaCl₂. Continuous voltage ramps were run with a speed of 0.46 ms per millivolt (thus, for example, 6 s per 130 mV). Different voltage ranges were chosen for different conditions. Currents were normalized to I_max. Lines are the sum of 8–10 individual measurements. SEM is indicated by gray errors bars. 50 nl EGTA (20 mM) was injected before the recordings. Squares represent the E_revs that are plotted in B. HyNaC was activated by 2 µM RFamide I. (B) Ca²⁺-dependent shifts of the E_rev reveal a high Ca²⁺ permeability of HyNaC. E_revs of the highly Ca²⁺-permeable P2X4 receptor are shown for comparison and were similar to HyNaC. P2X4 was activated by 10 µM ATP.