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. 2012 Oct;140(4):361–374. doi: 10.1085/jgp.201210822

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© 2012 Longpré et al.

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Figure 7. — The conformational time course of SGLT1 in different conditions. The time courses were simulated for 10 s (events occurring during the first 0.5 s are depicted) in the presence of 90 mM [Na⁺]_o and (A) 0.1 mM [αMG]_o at −50 mV, (B) 5 mM [αMG]_o at −50 mV, and (C) 5 mM [αMG]_o at −150 mV. Short arrows above each panel indicate the completion of a cotransport cycle and conformational change from C₇ to C₁. The occupational probabilities of the seven states during the 10 s period are shown on the right side of each panel. In addition, conformations suggested by the structural data of the LeuT fold family have been assigned to states C₁ through C₇ to illustrate the behavior of SGLT1. The so-called thin gates are represented by orange sticks, and the green circles and yellow hexagons represent Na⁺ ions and glucose molecules.