Table 4A.
Comparison of glucose metabolism by HCQ and disease status among women not using prednisone, by mean value adjusted for age, disease duration, waist circumference, predrisone dose, CRP, menopausal status, and NSAID; plus (a) immunosuppressants and SLEDAI for women with SLE, or (b) nonbiologic DMARD (excluding HCQ) and TNF inhibitors for women with RA.
| Metabolism Factors | + HCQ | − HCQ | p |
|---|---|---|---|
| Fasting glucose, mg/dl | |||
| Women with SLE, n = 92 | 83.5 | 89.1 | 0.01 |
| Women with RA, n = 103 | 87.0 | 90.3 | 0.30 |
| logInsulin | |||
| Women with SLE | 2.53 | 2.54 | 0.93 |
| Women with RA | 2.45 | 2.26 | 0.15 |
| logHOMA-B | |||
| Women with SLE | 5.47 | 5.24 | 0.08 |
| Women with RA | 5.25 | 4.94 | 0.09 |
| logHOMA-IR | |||
| Women with SLE | 0.94 | 1.02 | 0.54 |
| Women with RA | 0.91 | 0.75 | 0.27 |
HCQ: hydroxychloroquine; SLE: systemic lupus erythematosus; RA: rheumatoid arthritis; HOMA-B: homeostasis model assessment - ß cell; HOMA-IR: homeostasis model assessment-insulin; CRP: C-reactive protein; NSAID: nonsteroidal antiinflammatory drug; SLEDAI: Systemic Lupus Erythematosus Disease Activity Index; DMARD: disease-moditying antirheumatic drug; TNF: tumor necrosis factor.