Table 1.
Frequency of RAS (K-RAS, N-RAS, H-RAS) mutations in different types of tumors
| Tumors | Frequency of K-RAS mutations | Total samples analyzed |
|---|---|---|
| pancreas | 57% | 5169 |
| large intestine | 33% | 30793 |
| biliary tract | 31% | 1555 |
| small intestine | 20% | 316 |
| lung | 17% | 15080 |
| endometrium | 14% | 2143 |
| ovary | 14% | 2956 |
| gastrointestinal tract (site indeterminate) | 8% | 49 |
| cervix | 7% | 637 |
| prostate | 7% | 1126 |
| soft tissue | 7% | 1070 |
| peritoneum | 6% | 86 |
| stomach | 6% | 2571 |
| haematopoietic and lymphoid tissue | 5% | 5762 |
| liver | 5% | 450 |
| urinary tract | 5% | 868 |
| breast | 4% | 544 |
| eye | 4% | 90 |
| genital tract | 4% | 25 |
| oesophagus | 4% | 359 |
| penis | 4% | 28 |
| testis | 4% | 432 |
| autonomic ganglia | 3% | 63 |
| salivary gland | 3% | 170 |
| skin | 3% | 1422 |
| upper aerodigestive tract | 3% | 1554 |
| thymus | 2% | 186 |
| thyroid | 2% | 4710 |
| bone | 1% | 231 |
| central nervous system | 1% | 1032 |
| kidney | 1% | 617 |
| Tumors | Frequency of N-RAS mutations | Total samples analyzed |
|---|---|---|
| skin | 18% | 4759 |
| NS | 17% | 282 |
| haematopoietic and lymphoid tissue | 10% | 8548 |
| thyroid | 7% | 4206 |
| autonomic ganglia | 6% | 102 |
| adrenal gland | 5% | 170 |
| ovary | 4% | 133 |
| soft tissue | 4% | 481 |
| liver | 3% | 310 |
| testis | 3% | 283 |
| upper aerodigestive tract | 3% | 807 |
| breast | 2% | 330 |
| cervix | 2% | 132 |
| large intestine | 2% | 1056 |
| pancreas | 2% | 248 |
| prostate | 2% | 530 |
| stomach | 2% | 215 |
| urinary tract | 2% | 655 |
| biliary tract | 1% | 213 |
| central nervous system | 1% | 995 |
| endometrium | 1% | 314 |
| eye | 1% | 103 |
| lung | 1% | 2851 |
| Tumors | Frequency of H-RAS mutations | Total samples analyzed |
|---|---|---|
| salivary gland | 15% | 161 |
| urinary tract | 10% | 1499 |
| cervix | 9% | 264 |
| upper aerodigestive tract | 9% | 1083 |
| penis | 7% | 28 |
| prostate | 6% | 500 |
| skin | 6% | 2100 |
| soft tissue | 5% | 712 |
| stomach | 4% | 384 |
| testis | 4% | 130 |
| thyroid | 4% | 3681 |
| pituitary | 3% | 300 |
| bone | 2% | 199 |
| thymus | 2% | 46 |
| adrenal gland | 1% | 135 |
| breast | 1% | 542 |
| endometrium | 1% | 291 |
| oesophagus | 1% | 161 |
In bold all somatic mutations that are higher than 10% of frequency. (Sanger mutation database: http://www.sanger.ac.uk/genetics/CGP/cosmic/).