Table 2.
Frequency of RAF (ARAF, BRAF, CRAF) mutations in different types of tumors
| Tumors | Frequency of ARAF mutations | Total samples analyzed |
|---|---|---|
| ovary | 4% | 27 |
| large intestine | 2% | 157 |
| Tumors | Frequency of BRAF mutations | Total samples analyzed |
|---|---|---|
| NS | 57% | 547 |
| skin^ | 39% | 7731 |
| thyroid | 38% | 19675 |
| genital tract | 12% | 33 |
| large intestine | 12% | 36546 |
| biliary tract | 11% | 242 |
| eye | 11% | 493 |
| ovary | 11% | 1898 |
| gastrointestinal tract | 6% | 31 |
| meninges | 5% | 19 |
| small intestine | 5% | 101 |
| central nervous system | 4% | 1312 |
| endometrium | 4% | 825 |
| prostate | 4% | 1130 |
| bone | 3% | 147 |
| breast | 3% | 424 |
| testis | 3% | 235 |
| adrenal gland | 2% | 154 |
| haematopoietic and lymphoid tissue | 2% | 1235 |
| lung | 2% | 3539 |
| oesophagus | 2% | 170 |
| pancreas | 2% | 503 |
| soft tissue | 2% | 1172 |
| upper aerodigestive tract | 2% | 723 |
| autonomic ganglia | 1% | 149 |
| cervix | 1% | 451 |
| liver | 1% | 145 |
| pituitary | 1% | 115 |
| salivary gland | 1% | 90 |
| stomach | 1% | 955 |
| urinary tract | 1% | 345 |
NS, nervous system;
^
BRAF V600E mutation has been demonstrated in a higher percentage of melanomas.
*
This percentage of mutations deserves further investigations; only 1 case of this type of cancer has been analyzed and demonstrated to be positive for CRAF mutations. In bold all somatic mutations that are superior to 10% of frequency. A high percentage of BRAF V600E mutations has recently been reported at American Society of Clinical Oncology 2011 in 47 consecutive patients with hairy cell leukemia (also published by Tiacci E. et al. on NEJM 2011 “BRAF Mutations in Hairy-Cell Leukemia”).(Sanger mutation database: http://www.sanger.ac.uk/genetics/CGP/cosmic/).