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. Author manuscript; available in PMC: 2012 Sep 25.
Published in final edited form as: Bone. 2011 Mar 17;48(6):1354–1361. doi: 10.1016/j.bone.2011.03.687

Fig. 2. C4-2b tumors were larger with greater cell proliferation in mineralized collagen matrices versus simple collagen matrices.

Fig. 2

Mineralized collagen and simple collagen matrices were implanted with 50,000 or 500,000 C4-2b cells and implanted subcutaneously into 4-week-old athymic mice. The tumor sizes from mice implanted with 500,000 C4-2b cells were compared at 2-weeks (a-b) (n=10, *p<0.01, versus collagen/tumor implant). The incidence of tumor formation was greater in mineralized compared to simple collagen implants in mice implanted with 50,000 C4-2b cells (c) (n=10, *p<0.01, versus collagen/tumor implant). (d) Representative images and quantitative results of of Ki-67 staining in regular and mineralized collagen/tumor sections. (n=8, * p<0.02).