. Author manuscript; available in PMC: 2012 Sep 25.

Published in final edited form as: Semin Cardiothorac Vasc Anesth. 2012 Feb 23;16(3):123–132. doi: 10.1177/1089253211436350

Table 1.

Current clinical trials on myocardial reperfusion injury (ClinicalTrials.gov)

Mechanism	Current clinical trials studies (Number)	Intervention	Example (largest ongoing clinical trials)
Preconditioning	5	Remote ischemic preconditioning (RIPC), Levosimendan, Nitrate	Remote Ischaemic Preconditioning for Heart Surgery (RIPHeart- Study) Number of enrolled patients: 2070
Postconditioning	9	Remote ischemic postconditioning, Erythropoietin, Epoetin alpha	DANish Study of Optimal Acute Treatment of Patients With ST- elevation Myocardial Infarction (DANAMI-3) Number of enrolled patients: 2000
Inflammation	4	Acetaminophen, Etanercept, Adenosine	Myocardial Protection With Adenosine During Primary Percutaneous Coronary Intervention in Pts With STEMI (PROMISE) Number of enrolled patients: 200
Metabolism	14	Melatonin, Metformin, Dipyridamol, Atorvastatin, Aminoimidazol- Carboxamid-Ribonukleotid (AICAR), Glucose-insulin-potassium (GIK), 5- Seco-4-nor-cholestan-5-one oxime-3- ol (TRO40303), Exenatide, Vitamin C, Perhexellin	Melatonins Effect on Ischemia-reperfusion Injury Following Acute Myocardial Infarction Number of enrolled patients: 60