Table A1.
Multivariate Associations Between AI Versus Tamoxifen Initiation in Women Age 55 Years and Older
| Variable | AIs First v Tamoxifen First |
|
|---|---|---|
| RR | 95% CI | |
| Age at diagnosis, years | ||
| 55-64 | 1 | Reference |
| 65-74 | 0.78 | 0.60 to 1.00 |
| ≥ 75 | 0.67 | 0.46 to 0.97 |
| BMI, kg/m2 | ||
| < 25.0 | 1 | Reference |
| 25.0-29.9 | 1.11 | 0.80 to 1.54 |
| ≥ 30.0 | 1.40 | 1.06 to 1.87 |
| Stage at diagnosis | ||
| I | 1 | Reference |
| IIA | 1.21 | 0.66 to 2.23 |
| IIB | 2.02 | 0.74 to 5.46 |
| Tumor size, cm | ||
| < 1.0 | 1 | Reference |
| 1.0-1.9 | 1.06 | 0.77 to 1.45 |
| ≥ 2.0 | 0.84 | 0.48 to 1.48 |
| Lymph node status | ||
| Negative | 1 | Reference |
| Positive | 0.89 | 0.50 to 1.59 |
| Definitive surgical procedure | ||
| Breast conservation | 1 | Reference |
| Mastectomy | 1.08 | 0.76 to 1.53 |
| Chemotherapy | ||
| No | 1 | Reference |
| Yes | 0.99 | 0.76 to 1.28 |
| Radiation therapy | ||
| No | 1 | Reference |
| Yes | 0.94 | 0.76 to 1.28 |
| Charlson score | ||
| 0 | 1 | Reference |
| 1 | 1.20 | 0.91 to 1.58 |
| ≥ 2 | 0.87 | 0.58 to 1.28 |
| Year of diagnosis | ||
| 2001 | 1 | Reference |
| 2002 | 1.80 | 0.92 to 3.52 |
| 2003 | 1.32 | 0.65 to 2.39 |
| 2004 | 2.84 | 1.50 to 5.38 |
| 2005 | 4.04 | 2.21 to 7.38 |
| 2006 | 3.77 | 2.06 to 6.88 |
| 2007 | 4.15 | 2.26 to 7.60 |
| 2008 | 4.24 | 2.26 to 7.95 |
Abbreviations: AI, aromatase inhibitor; BMI, body mass index; RR, relative risk.
* All variables in the table are adjusted for each other.