Table 2.
Genotyping results forABCB11 c.1331 T > C from patients and controls
|
ABCB11p.V444A (c.1331 T > C) alleles/genotypes |
Counts (frequencies) of alleles/genotypes |
|
|---|---|---|
| Cases (N = 649) | Controls (N = 413) | |
| [T] |
511 (0.39) |
359 (0.43) |
| [C] |
787 (0.61) |
467 (0.57) |
| [TT] |
97 (0.15) |
82 (0.20) |
| [TC] |
317 (0.49) |
195 (0.47) |
| [CC] |
235 (0.36) |
136 (0.33) |
|
Tests for association |
chi2 |
P |
| Allele frequency difference |
3.50 |
0.061 |
| Armitage’s trend test |
3.49 |
0.062 |
|
OR statistics |
OR (95% CI) |
P |
| [C] ↔ [T] |
1.18 (0.99 - 1.41) |
0.061 |
| [CC] ↔ [TT] |
1.46 (1.02 - 2.10) |
0.040 |
| [CC + CT] ↔ [TT] | 1.41 (1.02 - 1.95) | 0.037 |
Patients with HCV infections are regarded as cases.
Abbreviations: A, alanine; ABCB11, ATP-binding cassette, subfamily B, member 11; CI, confidence interval; OR, odds ratio; p, protein (amino acid number), V, valine.