Table 3.
Th17 cells in viral infections.
| Virus | Organism | Comments | Ref. |
|---|---|---|---|
| Possible detrimental role | |||
| Influenza virus | Mouse | Immunopathology and inhibit CTL responses | [58] |
| MHV | Mouse | Immunopathology | [56] |
| HCV | Human | Immunopathology | [57] |
| HSV | Mouse | Exacerbate immunopathology caused by CTLs | [59] |
| TMEV | Mouse | Inhibit CTL response, leading to a persistent viral infection | [79] |
| CVB3 | Mouse | Immunopathology and possibly inhibit CTL responses | [102,103] |
| Possible protective role | |||
| HIV | Human | Depletion may lead to secondary infections | [61,63] |
| SIV | PT AGM |
Depletion correlates with pathogenesis No observable effects on Th17 cells (these monkeys develop a nonpathogenic chronic infection) |
[62] |
| Influenza virus | Mouse | Tc17 cells can contribute to viral clearance | [66] |
AGM: African green monkey; CTL: Cytotoxic T lymphocyte; CVB3: Coxsackie virus B3; MHV: Mouse hepatitis virus; PT: Pigtailed macaque; Tc: Cytotoxic T; TMEV: Theiler’s murine encephalitis virus; WNV: West Nile virus.