Table 2. DNMT1 polymorphisms for H.pylori seropositivity in control groups.
Genotype | H.pylori(+) | H.pylori(−) | OR(95%CI)* | P value |
(n = 478)(%) | (n = 483)(%) | |||
rs10420321 | ||||
A/A | 38.5 | 29.8 | Reference | |
A/G | 45.0 | 49.5 | 0.62(0.43–0.90) | 0.01 |
G/G | 16.5 | 20.7 | 0.70(0.53–0.94) | 0.02 |
A/G+G/G | 61.5 | 70.2 | 0.68(0.52–0.89) | 0.01 |
rs16999593 | ||||
T/T | 70.3 | 66.9 | Reference | |
T/C | 27.0 | 29.8 | 0.87(0.66–1.16) | 0.34 |
C/C | 2.7 | 3.3 | 0.80(0.38–1.69) | 0.55 |
rs8101866 | ||||
C/C | 48.3 | 53.4 | Reference | |
C/T | 43.9 | 39.8 | 1.25(0.76–2.07) | 0.38 |
T/T | 7.7 | 6.8 | 1.23(0.94–1.60) | 0.13 |
rs8111085 | ||||
T/T | 38.9 | 29.8 | Reference | |
T/C | 44.4 | 48.7 | 0.70(0.52–0.93) | 0.03 |
C/C | 16.7 | 21.5 | 0.60(0.42–0.86) | 0.01 |
T/C+C/C | 61.1 | 70.2 | 0.67 (0.51–0.87) | 0.01 |
rs2288349 | ||||
G/G | 51.9 | 55.3 | Reference | |
G/A | 38.7 | 38.7 | 1.06(0.81–1.38) | 0.68 |
A/A | 9.4 | 6.0 | 1.67(1.02–2.75) | 0.04 |
Haplotpe | ||||
GTCCG | 22.5 | 27.4 | Reference | |
ATTTG | 29.6 | 26.2 | 1.38(1.08–1.77) | 0.01 |
ATCTA | 28.6 | 25.1 | 1.40(1.09–1.80) | 0.01 |
GCCCG | 16.2 | 17.8 | 1.13(0.85–1.50) | 0.39 |
ATCTG | 2.7 | 2.4 | 1.41(0.78–2.54) | 0.25 |
OR were calculated by age and sex adjusted logistic regression model.