Table 2. The most overrepresented biological terms associated with probes significantly differentially expressed in the microarray experiments comparing field An. arabiensis populations from Burkina Faso (DSSBA RES and DSSBA CON) and an insecticide-susceptible strain from Mozambique (MOZ SUS).
| Microarray comparison | Category | Term | No. of probes | % | p-value Δ | Fold Enrichment |
| DSSBA RES vs. MOZ SUS * | GOTERM_MF_FAT | GO:0046906∼tetrapyrrole binding | 27 | 2.72 | 0.00715 | 2.473 |
| GOTERM_MF_FAT | GO:0020037∼heme binding | 27 | 2.72 | 0.00715 | 2.473 | |
| SP_PIR_KEYWORDS | Iron | 24 | 2.42 | 0.02218 | 2.346 | |
| COG_ONTOLOGY | Secondary metabolites biosynthesis, transport, and catabolism | 20 | 2.01 | 0.02298 | 2.186 | |
| SP_PIR_KEYWORDS | Monooxygenase | 17 | 1.71 | 0.02632 | 2.695 | |
| GOTERM_MF_FAT | GO:0005506∼iron ion binding | 33 | 3.32 | 0.02643 | 2.010 | |
| SP_PIR_KEYWORDS | heme | 19 | 1.91 | 0.03231 | 2.397 | |
| DSSBA RES vs. DSSBA CON | PIR_SUPERFAMILY | PIRSF000503:glutathione transferase | 7 | 2.37 | 0.00007 | 14.163 |
| INTERPRO | IPR004045:Glutathione S-transferase, N-terminal | 9 | 3.05 | 0.00023 | 11.649 | |
| INTERPRO | IPR017933:Glutathione S-transferase/chloride channel, C-terminal | 9 | 3.05 | 0.00025 | 10.590 | |
| INTERPRO | IPR004046:Glutathione S-transferase, C-terminal | 8 | 2.71 | 0.00082 | 10.712 | |
| INTERPRO | IPR010987:Glutathione S-transferase, C-terminal-like | 8 | 2.71 | 0.00100 | 10.021 | |
| DSSBA CON vs. MOZ SUS * | SP_PIR_KEYWORDS | oxidoreductase | 26 | 6.30 | 3.28E−07 | 4.081 |
| SP_PIR_KEYWORDS | heme | 18 | 4.36 | 5.30E−07 | 5.650 | |
| SP_PIR_KEYWORDS | iron | 19 | 4.60 | 3.22E−06 | 4.622 | |
| SP_PIR_KEYWORDS | Monooxygenase | 15 | 3.63 | 3.33E−06 | 5.917 | |
| INTERPRO | IPR017973:Cytochrome P450, C-terminal region | 17 | 4.12 | 3.41E−06 | 5.992 | |
| INTERPRO | IPR017972:Cytochrome P450, conserved site | 17 | 4.12 | 5.62E−06 | 6.069 | |
| COG_ONTOLOGY | Secondary metabolites biosynthesis, transport, and catabolism | 17 | 4.12 | 8.61E−06 | 4.096 | |
| INTERPRO | IPR001128:Cytochrome P450 | 17 | 4.12 | 1.34E−05 | 5.319 | |
| GOTERM_BP_FAT | GO:0055114∼oxidation reduction | 31 | 7.51 | 1.54E−05 | 3.019 | |
| GOTERM_MF_FAT | GO:0046906∼tetrapyrrole binding | 19 | 4.60 | 0.0002 | 3.961 | |
| GOTERM_MF_FAT | GO:0020037∼heme binding | 19 | 4.60 | 0.0002 | 3.961 | |
| INTERPRO | IPR002401:Cytochrome P450, E-class, group I | 13 | 3.15 | 0.0010 | 5.028 | |
| GOTERM_MF_FAT | GO:0005506∼iron ion binding | 21 | 5.08 | 0.0027 | 2.911 | |
| GOTERM_MF_FAT | GO:0009055∼electron carrier activity | 19 | 4.60 | 0.0036 | 2.988 | |
| INTERPRO | IPR013781:Glycoside hydrolase, subgroup, catalytic core | 10 | 2.42 | 0.0069 | 5.460 | |
| SP_PIR_KEYWORDS | metal-binding | 29 | 7.02 | 0.0128 | 1.969 | |
| INTERPRO | IPR016040:NAD(P)-binding domain | 14 | 3.39 | 0.0258 | 3.276 | |
| SP_PIR_KEYWORDS | glycosidase | 5 | 1.21 | 0.0380 | 8.109 | |
| GOTERM_MF_FAT | GO:0043169∼cation binding | 68 | 16.46 | 0.0435 | 1.420 | |
| GOTERM_MF_FAT | GO:0043167∼ion binding | 68 | 16.46 | 0.0435 | 1.420 | |
| INTERPRO | IPR002198:Short-chain dehydrogenase/reductase SDR | 9 | 2.18 | 0.0478 | 4.557 |
*
Functional annotation performed on genes commonly expressed in both DSSBA RES and DSSBA CON compared with MOZ SUS strain.
Δ
p-value after Benjamini-Hochberg multiple testing correction.