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. 2012 Sep 25;7(9):e46340. doi: 10.1371/journal.pone.0046340

Figure 5. Decreased dendritic spine density and mEPSC amplitude in the DG of Arf4+/− mice compared to WT mice.

Figure 5

(A) Representative dendrites for DG granule cells of WT and Arf4+/− mice at 4 months of age (n = 4 mice/genotype). (B) Averaged total spine density per µm dendrite length in the dentate gyrus of WT and Arf4+/− mice (28–30 neurons/genotype). (C) Spine densities for specific spine subtypes in the DG of WT and Arf4+/− mice. (D–F) Electrophysiological recordings reveal a decrease in amplitude of mEPSCs in Arf4+/− (n = 9 cells) compared to WT controls (n = 6 cells) at 2 months of age. All data are mean±SEM. * p<0.05, ** p<0.01, *** p<0.001. (G–H) Spontaneous mEPSC frequency is not altered in Arf4+/− granule cells (n = 9 cells) compared to WT granule cells (n = 6 cells) at 2 months of age.