Table 1. Baseline and operative characteristics of the cohort.
| Baseline Characteristics | Cohort Subset (n = 316) |
| Gender, n (%) | |
| Female | 136 (43.0%) |
| Male | 180 (57.0%) |
| Ethnicity, n (%) | |
| Asian/Pacific Islander, Hispanic, or other ancestry | 37 (11.7%) |
| African ancestry, not Hispanic | 70 (22.2%) |
| European ancestry, not Hispanic | 209 (66.1%) |
| Gestational Age, mean ± SD, weeks | 38.6±1.93 |
| Birth weight, mean ± SD, kg | 3.18±0.59 |
| Birth head circumference, mean ± SD, cm | 33.7±1.98 |
| APOE Genotype, n (%) a | |
| ε2 | 43 (13.6%) |
| ε3 | 187 (59.2%) |
| ε4 | 86 (27.2%) |
| Diagnostic Class, n (%) | |
| I: 2 ventricles, no arch obstruction | 160 (50.6%) |
| II: 2 ventricles, arch obstruction | 36 (11.4%) |
| III: 1 ventricle, no arch obstruction | 31 (9.8%) |
| IV: 1 ventricle, arch obstruction | 89 (28.2%) |
| Specific CHD Diagnoses, n (%) | |
| Hypoplastic Left Heart Syndrome | 87 (27.5%) |
| Tetralogy of Fallot | 52 (16.5%) |
| Transposition of the Great Arteries | 30 (9.5%) |
| Ventricle Septal Defect | 28 (8.9%) |
| Ventricle Septal Defect, Coarctation of Aorta | 15 (4.7%) |
| Single Ventricle | 23 (7.3%) |
| Other Distinct CHD Diagnoses | 81 (25.6%) |
| Preoperative intubation, n (%) | 91 (28.8%) |
| Preoperative length of stay, mean ± SD, days | 2.16±2.74 |
| Age at first operation, mean ± SD, days | 41.3±53.9 |
| Weight at first operation, mean ± SD, kg | 3.91±1.26 |
| Total cardiopulmonary bypass time in first operation, mean ± SD, min | 66.2±40.4 |
| Use of DHCA, n (%) | 180 (56.9%) |
| Total DHCA time in first operation, mean ± SD, min | 39.8±16.7 |
| Hematocrit level after hemodilution in first operation, mean ± SD, % | 28.0±3.99 |
| Postoperative length of stay after first operation, mean ± SD, days | 10.70±9.91 |
Abbreviations: SD = standard deviation. DHCA = deep hypothermic circulatory arrest.
a
APOE genotypes were categorized into three groups: ε2 (ε2ε2, ε2ε3, or ε2ε4), ε3 (ε3ε3), and ε4 (ε3ε4 or ε4ε4).