Table 3. Top SNP Results for Selected Four-Year Outcomes.

SNP	Chr	Positiona	ClosestReferenceGeneb	Distance to Closest Reference Gene	Minor/Major Alleles	MAF	EA only Betac,d	Betac	EA only P d	P
Top GWAS SNPs associated with ADHD-IV Hyperactivity/Impulsivity Scale c
rs4659682	1	233,008,289	LGALS8	–	G/A	0.042	2.146	2.313	2.33×10−4	1.03×10−6
rs7625411	3	114,294,118	(GTPBP8)	72,873 bp	C/T	0.177	2.956	2.779	4.98×10−4	3.84×10−6
rs543533	12	128,025,510	NLRP9P	–	C/T	0.377	−2.157	−2.07	9.67×10−5	7.67×10−6
Top GWAS SNPs associated with CBCL/1.5-5 PDPs c
rs2261722	9	76,099,135	PCSK5	–	C/T	0.317	3.037	3.137	2.82×10−5	1.11×10−6
rs10516292	4	15,425,972	(BST1)	15,907 bp	C/T	0.219	3.688	3.92	2.63×10−4	1.47×10−6
rs11206315	1	54,455,429	SSBP3	–	G/A	0.157	4.264	3.982	1.01×10−5	6.25×10−6
rs12965975	18	71,438,271	(C18orf62)	169,694 bp	C/T	0.393	1.723	3.086	0.0277	8.68×10−6
rs228144	6	55,739,721	BMP5	–	C/T	0.112	3.142	4.407	3.23×10−3	9.83×10−6
Top GWAS SNPs associated with CBCL/1.5-5 Total Problems c
rs11617488	13	21,091,962	(FGF9)	51,253 bp	C/T	0.275	−4.453	−5.245	5.13×10−4	3.47×10−7
rs9879307	3	9,845,065	TTLL3	–	C/T	0.317	−3.592	−0.2014	9.94×10−3	1.2×10−6

Chr  =  chromosome. EA  =  European Ancestry. GWAS  =  genome-wide association study. MAF  =  minor allele frequency. SNP  =  single nucleotide polymorphism.

^aPosition information and annotation from reference assembly 36.3.

^bSNPs not found within a gene region are represented in parentheses, e.g. (GTPBP8).

^cAll beta-coefficients and p-values are the result of linear regression, where the outcome was the residual phenotype, adjusted for by the covariates listed in the methods.

^dAnalysis performed on the majority genetic descent group (EA) of the cohort (n = 209), adjusting for all covariates in the methods.